Duration of treatment: 7 to 12 days. 1 patch stays in place for around 8 to 10 hours. Wash your hands thoroughly before applying the patch. Make sure the cold sore area is clean, dry and free of cream. - Remove the patch from its packaging. Hold the 2 applicators surrounding the patch with each hand. Gently remove one of the applicators by pulling on it according to the arrows. - Using the mirror, carefully apply the adhesive half of the patch to the cold sore. Press gently on the patch, with the patch to position it well on the pimple. - Remove the 2nd applicator by pulling on it gently until the patch comes off. Press the patch again so that it adheres well to the pimple. - Apply, if necessary, make-up to the patch. PRECAUTION FOR USE: Never apply the patch on cream. It could not adhere to the skin. Do not touch the cold sore. In case of contact, wash hands immediately. During a flare-up, do not rub your eyes or eyelids. Avoid contact with babies, children, sick or immunocompromised people. Avoid sharing glasses, cups, plates, linens or toiletries. If you wear contact lenses, never moisten them with saliva.