Take 4 capsules per day orally, with a large glass of water and preferably in the middle of meals. Inform your doctor and/or pharmacist if you are taking medication at the same time. St. John's wort intervening in the enzymatic system it can decrease or increase the effectiveness of many drugs. The only serious contraindication is heart problems that taking St. John's wort can accentuate (palpitations, arrhythmia, etc.) and it is therefore advisable to be very careful during parallel uses with anti-depressants or neuroleptics.